LACKO, Andras, G.,SABNIS, Nirupama, A.,SHAH, Sunil,MOOBERRY, Linda, K.
申请号：
USUS2018/028498
公开号：
WO2018/195382A1
申请日:
2018.04.20
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides high density lipoprotein (HDL) or reconstituted HDL (rHDL) particles for the delivery of therapeutic agents or nucleic acids to cells and tissues. The use of HDL or rHDL particles has advantages over other delivery systems because they are smaller in size and their contents are rapidly internalized by receptors of specific cells, including receptors on the surface of tumor tissue. The HDL or rHDL nanoparticles of the present invention may include a positively charged polyamino acid, which neutralizes the negatively charged nucleic acid, thus allowing for successful incorporation of the nucleic acid into an HDL or rHDL particle. Methods of delivering therapeutic agents to cells and target tissues using the disclosed HDL or rHDL particles are provided as are methods of treating various diseases and disorders. Also provided are high density lipoprotein (HDL) or reconstituted HDL (rHDL) particles for the delivery of non-nucleic acid based therapeutic agents to cells and tissues. The use of HDL or rHDL particles has advantages over other delivery systems because they are smaller in size and their contents are rapidly internalized by receptors of specific cells, including receptors on the surface of tumor tissue. Methods of delivering non-nucleic acid based therapeutic agents to cells and target tissues using the disclosed HDL or rHDL particles are also provided for treating various diseases and disorders.La présente invention concerne des particules de lipoprotéine haute densité (HDL) ou de HDL reconstituée (rHDL) pour l'administration d'agents thérapeutiques ou d'acides nucléiques à des cellules et des tissus. L'utilisation de particules de HDL ou rHDL présente des avantages par rapport à d'autres systèmes de distribution parce qu'elles sont de taille plus petite et leur contenu est rapidement internalisé par des récepteurs de cellules spécifiques, comprenant des récepteurs sur la surface de tissu tumoral. Les nanoparticules de HDL ou rHDL
