ISTITUTO DI RICHERKE DI BIOLODZHIA MOLEKOLARE P.ANDZHELETTI S.P.A.
发明人:
LIVERTON NAJDZHEL DZH.,ЛИВЕРТОН Найджел Дж.,SUMMA VINCHENTSO,СУММА Винченцо,DI FRANCHESKO MARIJA EHMILIJA,ДИ ФРАНЧЕСКО Мария Эмилия,FERRARA MARKO,ФЕРРАРА Марко,GILBERT KEVIN F.,ГИЛБЕРТ Кевин Ф.,KHARPE
申请号：
RU2009120056/04
公开号：
RU0002468029C2
申请日:
2007.10.23
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
FIELD: medicine.SUBSTANCE: invention relates to macrocyclic compounds of formula (I), which can be used as inhibitors of NS3 protease of hepatitis C virus (HCV), to their synthesis and their application for treatment or prevention of HCV infection. Compound of formula (I) and its pharmaceutically acceptable salt, in which is selected from group, consisting of group of cycles, whose value is given in i.1 of the formula, with being substituted with from 0 to 4 substituents, selected from W, R5 or oxo with said substituents W and R5 being located on one or more ring atoms, selected from C and N R1 is selected from group, consisting of -CO2R10 and -CONR10SO2R6 R2 is selected from group, consisting of C1-C6 alkyl and C3-C6 alkenyl R3 is selected from group, consisting of H, C1-C8 alkyl and C3-C8 cycloalkyl R5 is selected from group, consisting of H, halogen atoms, -OH, C1-C6 alkoxy, C1-C6 alkyl, -CN, -CF3, -OCF3, -C(O)OH, -C(O)CH3, C1-C6halogenalkyl, phenyl, naphthyl and -O-phenyl R6 is selected from group, consisting of C3-C6 cycloalkyl and said R6 are substituted with from 0 to 2 independently selected substituents W Y is selected from group, consisting of -C(O)-, -OC(O)-, -C(O)N(D)L- and -LN(D)C(O)-, where D is selected from group, consisting of H and C1-C6 alkyl, is selected from group, consisting of direct bond, groups -G-(C1-C6 alkylene)- and (C1-C6 alkylene)-G-, where said G stands for -O-, said alkylene and alkenylene are substituted with from 0 to 4 substituents E, independently selected from group, consisting of C1-C6 alkyl, and said D and E can together form 3-6-membered ring, containing from 0 to 3 N atoms Z is selected from group, consisting of -C(O)- and direct bond M is selected from group, consisting of C1-C12 alkylene and C2-C12 alkenylenes, and said M is substituted with from 0 to 2 substituents RA, independently selected from group, consisting of C1-C6 alkyl, =CH2, and 2 adjacent substituents R71 can together with atoms, which they are bound to, for
