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Human anti-XCR1 antibodies
专利权人:
Ltd.;Eisai R&D Management Co.
发明人:
SAKAMOTO, Yoshimasa,NISHIMURA, Miyuki,KAWANO, Tetsu,SAWA, Yukihisa,IMAI, Toshio
申请号:
ES12761822
公开号:
ES2684173T3
申请日:
2012.08.30
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
An antibody that binds to human XCR1, where the antibody is: the antibody comprising a heavy chain variable region comprising the heavy chain CDR 1-3 described in (g) - (i) below and a variable region of the light chain comprising the CDR 1-3 of the light chain described in (j) - (1) below; the antibody comprising a heavy chain variable region comprising CDR 1-3 of the heavy chain described in (m) - (o) below and a variable region of the light chain comprising CDR 1-3 of the light chain described in (p) - (r) below; or the antibody comprising a heavy chain variable region comprising CDR 1-3 of the heavy chain described in (a) - (c) below and a variable region of the light chain comprising CDR 1- 3 of the light chain described in (d) - (f) below: (a) a heavy chain CDR 1 consisting of the amino acid sequence of SEQ ID NO: 41, (b) a CDR 2 of the heavy chain consisting of the amino acid sequence of SEQ ID NO: 42, (c) a CDR 3 of the heavy chain consisting of the amino acid sequence of SEQ ID NO: 43; (d) a CDR 1 of the light chain consisting of the amino acid sequence of SEQ ID NO: 44, (e) a CDR 2 of the light chain consisting of the amino acid sequence of SEQ ID NO: 45, and 25 (f) a CDR 3 of the light chain consisting of the amino acid sequence of SEQ ID NO: 46; (g) a CDR 1 of the heavy chain consisting of the amino acid sequence of SEQ ID NO: 17, (h) a CDR 2 of the heavy chain consisting of the amino acid sequence of SEQ ID NO: 18, (i ) a CDR 3 of the heavy chain consisting of the amino acid sequence of SEQ ID NO: 19; (j) a CDR 1 of the light chain consisting of the amino acid sequence of SEQ ID NO: 20, (k) a CDR 2 of the light chain consisting of the amino acid sequence of SEQ ID NO: 21, (l ) a CDR 3 of the light chain consisting of the amino acid sequence of SEQ ID NO: 22; (m) a CDR 1 of the heavy chain consisting of the amino acid sequence of SEQ ID NO: 29, (n) a CDR 2 of the heavy chain consisting of the amino acid sequence of SEQ ID NO: 30, (or ) a CDR 3 of the hea
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