Novel binder-drug conjugates (ADCs) and their use

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专利权人:

Bayer Intellectual Property GmbH;Bayer Pharma Aktiengesellschaft

发明人:

Lerchen, Hans-Georg,El Sheikh, Sherif,Beier, Rudolf,Bruder, Sandra,Stelte-Ludwig, Beatrix,Jorissen, Hannah,Mahlert, Christoph,Greven, Simone,Petrul, Heike,Schuhmacher, Joachim,Linden, Lars,Willuda, Jo

申请号：

AU2012244673

公开号：

AU2012244673A1

申请日:

2012.04.20

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

The present application relates to novel, anti-Target Epidermal Growth Factor Receptor (EGFR, GeneID1956) binder-drug conjugates (ADCs) of N,N-dialkyl auristatins, to effective metabolites of said ADCs, to methods for producing said ADCs, to the use of said ADCs for treating and/or preventing diseases, and to the use of said ADCs for producing pharmaceuticals for treating and/or preventing diseases, in particular hyperproliferative and/or angiogenic diseases, such as cancers. Such treatments can be carried out as monotherapy or in combination with other pharmaceuticals or additional therapeutic measures.

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中国工程科技知识中心

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