Hans-Georg Lerchen,Lars Linden,Sherif El Sheikh,Jörg Willuda,Charlotte C. Kopitz,Joachim Schuhmacher,Simone Greven,Christoph Mahlert,Beatrix Stelte-Ludwig,Sven Golfier,Rudolf Beier,Iring Heisler,Axel
申请号：
US14113070
公开号：
US20140127240A1
申请日:
2012.04.20
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present patent application relates to novel binder-drug conjugates (ADCs) of N,N-dialkylauristatins directed against the target epidermal growth factor receptor (EGFR, gene ID 1956), effective metabolites of these ADCs, methods for producing these ADCs, use of these ADCs for treatment and or prevention of diseases as well as the use of these ADCs to produce pharmaceutical drugs for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic diseases such as cancer, for example. Such treatments may be administered as monotherapy or in combination with other pharmaceutical drugs or other therapeutic measures.
