The present invention relates to substituted dicyclic compound, the purposes of the pharmaceutical composition comprising such compound and the compound and composition in the treatment, the substituted dicyclic compound can be with what by combining what bromine structural domain to inhibit BET protein function.本發明涉及取代的雙環化合物、包含此類化合物的藥物組合物和所述化合物和組合物在治療中的用途,所述取代的雙環化合物可用於通過結合於溴結構域而抑制BET蛋白功能。