The present invention provides can be by combining what bromine structural domain to be used as the dicyclic compound of additional terminal domains BET protein function inhibitor newly replaced. Pharmaceutical composition comprising such compound prevents and treats disease relevant to bromine structural domain and additional terminal domains (BET) albumen and symptom with what.本發明提供可通過結合於溴結構域而用作額外末端結構域BET蛋白功能抑制劑的新取代的雙環化合物。包含此類化合物的藥物組合物用於預防和治療與溴結構域和額外末端結構域(BET)蛋白相關的疾病和病狀。
