The United States of America; as represented by the Secretary; Dept. of Health and Human Service
发明人:
Christopher D. Chien,Terry J. Fry
申请号：
US16304552
公开号：
US20190225697A1
申请日:
2017.05.26
申请国别(地区):
US
年份:
2019
代理人:
摘要：
An embodiment of the invention provides a chimeric antigen receptor (C AR) comprising an antigen binding domain specific for FLT3, a transmembrane domain, and an intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of a proliferative disorder, e.g., cancer, in a mammal and methods of treating or preventing a proliferative disorder, e.g., cancer, in a mammal are also disclosed.
