Rimas J. Orentas,Ira H. Pastan,Dimiter S. Dimitrov,Crystal L. Mackall
申请号：
US14437889
公开号：
US10072078B2
申请日:
2013.09.18
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention provides a chimeric antigen receptor (CAR) comprising an antigen binding domain comprising SEQ ID NOs: 1-6, a transmembrane domain, and an intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.
