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Asymmetric Derivatives Used as ATX/CA Double Inhibitors
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
MATTEI, PATRIZIO,HERT, JRME,HUNZIKER, DANIEL,RUDOLPH, MARKUS,SCHMITZ, PETRA,DI GIORGIO, PATRICK,GOMME, JUSTIN
申请号:
ARP180100599
公开号:
AR111279A1
申请日:
2018.03.15
申请国别(地区):
AR
年份:
2019
代理人:
摘要:
Proposition 1: Formula compound (1)R1 is selected from (1) phenyl substituted with r3.R83088 and R83099;(2) pyridine substituted with r3,R83088 and R83099;(3) substituting sulfur and phosphorus with r3;R830808 and R83099;X is selected from (i) n.(2) CH;And from (i) - Ch832222 - OC (o),2-(Ch832222)QC(O)-,(3) - (ch = ch) 691 - C (o) -,And (4) - (ch) 691 - C (o) -;W was selected from (i) (Cr.8313; R1 830404).;(ii) - (Cr8313); (R830446); - C (o) -,3-(Cr8313); (R83044); - O-,4-(Cr8313); (R83044); - S-,Five (Cr 8313); R830446; - S (o) - and (vi) - (Cr. 83313); R1830446; - S (o) 83222-;R2 is selected from (i) substituted phenyl.There, the phenyl ring is replaced by R8310.R831181 and R831222,Disubstituted pyridineThere, the Piridiniro ring was replaced by R8310A.R831181 and R831222,Trisubstituted sulfur and phosphorus;There, Tiofeni's ring was replaced by R8310.R831181 and R831222,And (4) substituted thiazoles,(a) The thiazole ring was replaced by R8310A;R831181 and R831222;R3 was selected from (i) Halo-Alcoxi C83216C8331832626;(ii) cycloquilo C83323318328;(3) Cyokquil C832-833318328;(iv) cycloquil C83223 degrees-83318328;Five Cycloalcoxi C83223-83318328;Six Cycloalcoxi C832-833318328 Na-asphalt C8321833126;(7) Methyl tetracarboate,(8) trimethyl,(9) Methyl pyrazole ester,(x) C832121883318326; tetrazolilmethy,(11) C832121883318326; Triazolilmethy,(12) C832121 bitumen; Pirazolilmethy;(13) Isopropyl-alcoxi C83218331832626;R830808 from,(i) Halogens,(2) HIDROXI,(3) Cyanide,Rent No. 4 C83218C8331832626;Five Alcox C83218d 8331832626;Six Alcoxi C83217D.83318326A-Rent C83218C83312626;(vii) Halo-Alcoxi C83218331832626;(viii) Halo-Acquilo C83218331832626;(ix) hydroxi-codilo C83213531832626;(x) cycloquilo C83323318328;(xi) cyclokquil C832-833318328;(12) Cyokquil C83223-83331;(13) Cycloalcoxi C8323-83318328;(14) Cycloalcoxi C832-833318328;(15) C83218C83318326 tar;(16) Cyoquil C83223-83318328; "Carnilamino;R83099 was selected from (i) H.(2) Halogens,(3) HIDROXI,(4) Cyanide,(v) Rent No. C
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