DE TITTA, Alexandre,DE VISSCHER, Geofrey,TAKEIRI, Mayu,SCHÜWER, Nicolas
申请号：
EPEP2016/053462
公开号：
WO2016/135037A1
申请日:
2016.02.18
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The present invention relates to a codrug of a dianhydrohexitol having one of the following structures: Formula (1a) Formula (1b) Formula (1c) wherein D1 and D2 are drug moieties that are the same or different and are covalently linked to the dianhydrohexitol via a physiologically hydrolyzable bond； R1 and R2 are selected from the group consisting of hydrogen, -SO3M and a physiologically hydrolyzable chemical group, wherein M is a cation, and the physiologically hydrolyzable chemical group is selected from the group consisting of alkyl, alkenyl, alkylcarbonyl, alkenylearbonyl arylcarbonyl, heteroarylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, alkylether, alkenylether, arylether, and heteroarylether groups wherein the alkyl group or moiety consists of unsubstituted or substituted, straight-chain or branched-chain or cyclic alkyl groups having 1-22 carbon, atoms, wherein the alkenyl moiety consists of unsubstituted or substituted, straight-chain or branched-chain or cyclic alkenyl groups having 2-22 carbon atoms, wherein the aryl moiety consists of unsubstituted or substituted, phenyl, or phenalkyl groups wherein the alkyl moiety contains 1-3 carbon atoms and the phenyl moiety is unsubstituted or substituted, and the heteroaryl moiety is an aromatic 5- or 6-membered heterocyclic ring containing one or two heteroatoms selected from, the group consisting of nitrogen, oxygen, and sulphur. The invention also relates to the treatment of wounds and biofilm-associated inventions using these compounds,La présente invention concerne un co-médicament à base d'un dianhydrohexitol répondant à l'une des structures suivantes : Formule (1a) Formule (1b) Formule (1c) dans lesquelles D1 et D2 représentent des fractions médicamenteuses qui sont identiques ou différentes et sont liées de manière covalente au dianhydrohexitol par l'intermédiaire d'une liaison physiologiquement hydrolysable； R1 et R2 sont choisis dans le groupe constitué par un atome d'hydrogène, -SO
