Methods and compositions for treating or preventing narcotic withdrawal symptoms

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专利权人:

Gary Peltz

发明人:

Gary Peltz,David Clark,Lawrence Chu

申请号：

US12631628

公开号：

US09226918B2

申请日:

2009.12.04

申请国别(地区):

US

年份:

2016

代理人:

摘要：

This invention provides methods and pharmaceutical compositions for preventing or treating physical dependence and/or withdrawal associated with narcotic use, in particular by modulating a 5-HT3 receptor. Using a computational genetic approach in mice, a gene conserved between mice and humans was identified as candidate as a modulator of physical dependence to morphine. Administration of compounds that modulate 5-HT3 receptors was found to control withdrawal from morphine in mice and humans.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/