Methods and compositions of reducing or eliminating the symptoms of withdrawal from drug or alcohol in drug or alcohol-dependent persons, while restoring the patient to nutritional health.The methods including parenteral administration of solutions containing high doses of ascorbic acid.Compositions of the invention comprise at least about 20%(w), or at least about 25%(w), or at least about 30%(w), or at least about 35%(w), or at least about 38%(w) of ascorbic acid and a local anesthetic.