(57)< Abstract > This invention being manufacturing method of the control discharge characteristic medical supply which possesses particle content coating, the said coating, regards the above-mentioned manufacturing method which is obtained from the water dispersed liquid of the water insoluble membrane formation characteristic polymer and the water soluble pore formation medicine. Replacing to melting the pore formation medicine, the suspension being specified grain size, it disassembles the coating which is obtained by being able to point, in the body fluids, or when melting, it contains the pore formation medicine particle which possesses the said grain size which creates the plural grooves or the network of the pore which pass the said polymer membrane. Originating in this network, the aforementioned polymer membrane acquires the mechanical stability which is superior, in addition, after the medicine is discharged, is not broken.本発明は、粒子含有コーティングを有する制御放出性医薬品の製法であって、該コーティングを、水不溶性の膜形成性ポリマーと水溶性の細孔形成剤との水性分散液から得る上記製法に関する。細孔形成剤を溶解することに代えて、懸濁させることによって、得られるコーティングは、所定粒径であって、体液中で分解するか又は溶解したとき該ポリマー膜を通過する複数の溝又は細孔の網状組織を創り出す該粒径を有する細孔形成剤粒子を含有する。この網状組織に起因して、前記ポリマー膜は、優れた機械的安定性を獲得し、また、薬剤が放出された後、壊れない。
