XIN TAO,LI WANREN,WODZINSKA JOLANTA MARIA,RABADIA VRAJLAL S.,FEENEY CHRISTOPHER JOHN,TAM TIM FAT,LEUNG-TOUNG REGIS,WANG YINGSHENG,ZHAO YANQING
申请号：
NZ61588012
公开号：
NZ615880A
申请日:
2012.03.30
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Provided are prodrugs of D-isoglutamyl-[D/L]-tryptophan of formula (I), where the variables are as defined in the specification. Examples of the prodrugs include H-D-Glu(D-Trp-OH)-OCH2CH2CF3 and H-D-Glu(D-Trp-O-CH(CH3)-O-CO-O-cyclohexyl)-OH. Further provided is the use of the pro-drugs in pharmaceutical compositions. D-isoglutamyl-D-tryptophan and D-isoglutamyl-L-tryptophan may be useful in the treatment of various diseases, particularly those that are immune system related.
