Peptides with reduced toxicity that stimulate cholesterol efflux

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专利权人:

ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア

发明人:

ジョン ケー．ビエリッキー,ジャン ヨハンソン,ワリード ダンホ

申请号：

JP2016503021

公开号：

JP6549554B2

申请日:

2014.03.14

申请国别(地区):

JP

年份:

2019

代理人:

摘要：

The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABCA1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.

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