MÉDAITEURS PEPTIDIQUES AMÉLIORÉS D'EFFLUX DE CHOLESTÉROL

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专利权人:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人:

BIELICKI, JOHN, K.,JOHANSSON, JAN

申请号：

EP09767675

公开号：

EP2300038A4

申请日:

2009.06.17

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABAC1 that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.

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