LEVY, ODILE ESTHER,JODKA, CAROLYN M.,GHOSH, SOUMITRA S.,PARKES, DAVID,PITTNER, RICHARD A.,D'SOUZA, LAWRENCE J.,AHN, JOHN S.,PRICKETT, KATHRYN S.,ROTH, JONATHAN DAVID,ADAMS, SEAN H.
申请号：
CA2588594
公开号：
CA2588594C
申请日:
2005.12.12
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention relates to novel Pancreatic Polypeptide Family("PPF") polypeptides. The PPF polypeptides of the invention generally includeatleast two PPF motifs and will generally retain a biological activity of a PP,PYY orNPY. PPF polypeptides of the invention include those having a potency in oneof theassays described herein (for example, food intake, gastric emptying,pancreaticsecretion, or weight reduction) which is greater than the potency of PP, NPY,PYY, orPYY(3-36) in the same assay. In some aspects, the PPF polypeptides of theinvention include novel PYY analog polypeptides. In other aspects, the PPFpolypeptides of the invention include PPF chimeric polypeptides comprising afragment of a PP family polypeptide linked to a fragment of a second PP familypolypeptide, wherein each fragment includes a PPF motif. Pharmaceuticalcompositions comprising PPF polypeptides of the invention, and methods ofusingthe PPF polypeptides of the invention, are also disclosed.
