The Invention provides a <； p >； conjugate, or a pharmaceutically acceptable Salt del u00a0mismo,Comprising a polypeptide Synthetic Formula I: <； BR / >； <； BR / >； Q - R - P - R - L - C - H - K - G - P - (NIE) * - C - F (R) or an amide or Ester thereof； and a Fatty Acid selected from: <； / p >； <； p >； Space formula <； / p >； <； p >； in the Fatty Acid est u00e1 u00a0unido covalently to extremo u00a0n - terminal p u00e9ptid A u00a0trav u00e9s or one of its functionalities of carboxylic acidOptionally through un u00a0enlazador of polyethylene glycol； and in which the two cysteine amino acids marked with "* " u00a0forman a disulfide bond between the thiol functionalities of its side chain. Los u00a0conjugados are APJ receptor agonists.The Invention also relates to a Manufacture m u00e9todo u00a0para Conjugates of the Invention and their Therapeutic uses, such como u00a0el Treatment or prevention of acute decompensated Heart Failure (ICAD), u00a0insuficiencia chronic Cardiac, pulmonary hypertension, fibrilaci u00f3 N de u00a0brugada Syndrome, atrial, ventricular tachycardia, hypertension, atherosclerosis, u00a0restenosis,Enfermedades u00a0isqu u00e9micas cardiovascular fibrosis, Cardiac arrhythmias, cardiomyopathy, diabetes (de u00a0agua Retention, including gestational diabetes), u00a0accidentes peripheral arterial disease, obesity, Stroke, transient ischemic attacks, injuries cerebrales u00a0traum u00e1ticas, Amyotrophic lateral sclerosis, Burns (including sunburn) y u00a0preeclampsia.The present Invention also provides a combination is active and a Pharmaceutical composition agentes u00a0farmacol u00f3gicamente. <； / p >；<；p>；La invención proporciona un conjugado, o una sal farmacéuticamente aceptable del mismo, que comprende un polipéptido sintético de Fórmula I:<；br />； <；br />； Q-R-P-R-L-C*-H-K-G-P-(Nie)-C*-F (I) o una amida o éster del mismo； y un ácido graso seleccionado de:<；/p>； <；p>；ESPACIO PARA F
