PROBLEM TO BE SOLVED: To provide a composition for prevention of virus infection such as influenza.SOLUTION: The present invention provides a composition for prevention of virus infection of a human or a nonhuman animal that is administered to an epithelial cell of the respiratory tract, gastrointestinal tract or eye tissue of the human or nonhuman animal, and comprises an antagonist bound to a virus receptor of the epithelial cell as an active ingredient.SELECTED DRAWING: Figure 2COPYRIGHT: (C)2020,JPO&INPIT【課題】インフルエンザなどウイルス感染症の予防用組成物の提供。【解決手段】ヒト又は非ヒト動物の気道、消化管又は眼組織の上皮細胞に投与され、該上皮細胞のウイルスレセプターに結合する拮抗物質を有効成分として含有する、ヒト又は非ヒト動物用のウイルス感染症予防用組成物。【選択図】図2