WANG QUN,RAJAN Saravanan,CHANG CHEW SHUN,HEIDBRINK THOMPSON JENNY,LIN HUNG YU,STOVER CHARLES KENDALL,PENNINI MEGHAN,DALLACQUA WILLIAM,CHOWDHURY PARTHA S,XIAO XIAODONG
申请号：
IN201817005580
公开号：
IN201817005580A
申请日:
2018.02.14
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
The present disclosure provides MrkA binding proteins, e.g., antibodies or antigen binding fragments thereof that bind to MrkA and induce opsonophagocytic killing of Klebsiella (e.g., Klebsiella pneumoniae). The present disclosure also provides methods of reducing Klebsiella (e.g., Klebsiella pneumoniae) or treating or preventing Klebsiella (e.g., Klebsiella pneumoniae) infection in a subject comprising administering MrkA binding proteins, e.g., antibodies or antigen-binding fragments thereof, MrkA polypeptides, immunogenic fragments thereof, or polynucleotides encoding MrkA or immunogenic fragments thereof to the subject.
