The present invention relates to protein-protein interactions involved in AIDS. More specifically the present invention relates to complexes of polypeptides or polynucleotides encoding the polypeptides, fragments of the polypeptides, antibodies to the complexes, selected Interacting Domains (SID®) which are identified due to the protein-protein interactions, methods for screening drugs of agents which modulates the interaction of proteins and pharmaceutical compositions that are capable of modulating the protein-protein interactions.