The wetting it does with low with the hydrophilic polymer which shows friction the process which has the base substance material which coat is done The hydrophilic polymer which is identical with the chemical reduction grain of the oligodynamic action metal, and those which is coat of the base substance material, the process which has the colloidal solution which is included And The process which soaks the said base substance material in that solutionIncluding, the manner which offers the medical device which becomes, possesses anti-bacterial activity is disclosed. In addition, following to that, also the medical device which is prepared is disclosed. With this manner, you can obtain the very profitable property of anti-bacterial coat. Especially, in the wetting fluid you can obtain relatively low discharge factor, in the usage condition which is intended, for example when it interposes in the urethra, you can obtain relatively high discharge factor.湿潤すると低摩擦を示す親水性ポリマーでコーティングされた基体材料を備える工程;微量作用金属の化学還元粒子、及び基体材料のコーティングにあるものと同一である親水性ポリマー、を含むコロイド溶液を備える工程;及び該基体材料をその溶液中に浸漬する工程;を含んでなる、抗菌活性を有する医療デバイスを提供する方法が開示される。また、それに従って調製される医療デバイスも開示される。この方法によって、抗菌コーティングの非常に有利な特性が得られる。特に、湿潤流体では相対的に低い放出率が得られ、意図した使用状況では、例えば尿道に挿入すると、相対的に高い放出率が得られる。
