Provided herein are transdermal delivery devices comprising tetrabenazine, a deuterated tetrabenazine, or a combination thereof. Also provided herein are pharmaceutical compositions, such as adhesive compositions, comprising tetrabenazine, a deuterated tetrabenazine, or a combination thereof, for example, homogenously dispersed in an adhesive, such as a pressure sensitive adhesive. Further provided herein are methods of using the transdermal delivery devices or pharmaceutical compositions, for example, for treating a hyperkinetic movement disorder.在此提供包含丁苯那嗪、一種氘化丁苯那嗪或它們的一組合的經皮輸送裝置。在此亦提供藥學組成物(諸如黏著劑組成物)，其包含丁苯那嗪、一種氘化丁苯那嗪或它們的一組合，例如，被均勻地分散在一黏著劑(諸如一壓敏黏著劑)。在此進一步提供使用該等經皮輸送裝置或藥學組成物，例如，用於治療一過動型運動疾患的方法。
