Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to human folate receptor 1 are provided. Methods of using the agents, antibodies, or immunoconjugates, such as methods of inhibiting tumor growth are further provided.提供新穎的抗癌劑,其包括但不限於結合至人類葉酸受體1之抗體與免疫共軛物。進一步提供使用該劑、抗體或免疫共軛物的方法,例如抑制腫瘤生長的方法。