Barbara Pui Chan;Ting Yan Hui;Danny Chan;Kenneth Man-Chee Cheung;Godfrey Chi-Fung Chan
发明人:
Barbara Pui Chan,Kenneth Man-Chee Cheung,Danny Chan,Godfrey Chi-Fung Chan,Ting Yan Hui
申请号：
US11742040
公开号：
US08734827B2
申请日:
2007.04.30
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A bioengineered IVD for disc replacement has been developed that has mechanical and structural support characteristics similar to those of native IVD. Extracellular matrix (ECM) provides support to living cell components and interacts with the living cellular components during the fabrication process without introducing toxicity. The composition can be produced from both natural or synthetic source but preferably natural and induced to self-assemble or reconstitute into its solid form under conditions that are mild enough to support cellular survival and growth. The cells induce a volume change of the structures, leading to changes in dimension, ECM density, cell density, mechanical property and stability, etc. The extent of the change in volume of the composition can be precisely controlled by factors such as the density of the ECM, the density of the living cells, the timing for interaction and the serum concentration. Increased structural support is provided by crosslinking.
