Yak-Nam Wang,Michael R. Bailey,Tatiana D. Khokhlova,Wayne Kreider,Adam D. Maxwell,George R. Schade,Vera A. Khokhlova
申请号：
US15126131
公开号：
US20170072228A1
申请日:
2015.03.30
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Methods and systems for selectively disrupting tissue using high intensity focused ultrasound (“HIFU”) therapy are disclosed herein. A method of treating tissue in accordance with an embodiment of the present technology can include, for example, pulsing HIFU waves from an ultrasound source toward a volume of tissue that includes an extracellular matrix (“ECM”) and generating, from nonlinear propagation of the HIFU waves, shock waves in the tissue to induce boiling in the volume of the tissue. The method can further include lysing cells in the volume of tissue while leaving the ECM at least substantially intact. The emulsification of cells can be to a sufficient degree to decellularize the tissue and form a decellularized scaffold for subsequent tissue growth.
