RECOMBINANT ATTENUATED CLOSTRIDIUM ORGANISMS AND VACCINE

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专利权人:

发明人:

申请号：

HK12100903.2

公开号：

HK1160600A

申请日:

2009.05.08

申请国别(地区):

HK

年份:

2012

代理人:

摘要：

The present invention discloses attenuated Clostridium perfringens organisms that express a substantially nontoxic alpha-toxin. The expressed alpha-toxin is a deletion mutein that relative to the alpha-toxin of the mature alpha-toxin of Clostridium perfringens strain 13, is missing at least nine consecutive amino acid residues including His68. The present invention also discloses attenuated organisms that encode the muteins, as well as the use of such attenuated organisms as vaccines.

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中国工程科技知识中心

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http://www.ckcest.cn/home/