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RECOMBINANT ATTENUATED CLOSTRIDIUM ORGANISMS AND VACCINE
专利权人:
SCHERING-PLOUGH; LTD
发明人:
COCHRAN, MARK, D,PETERSEN, GARY,LAIR, STEVEN, V,SYNENKI, RICHARD
申请号:
NZ57197007
公开号:
NZ571970A
申请日:
2007.04.12
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed is a nucleic acid molecule that encodes a substantially nontoxic mutein of Clostridium perfringens alpha-toxin. The mutein alpha-toxin comprises an amino acid sequence as defined in the complete specification minus at least 9 consecutive amino acid residues with no more than 48 consecutive amino acid residues deleted and wherein one of the deleted amino acid residues is His68.
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