A novel method of inducing or producing pancreatic beta cells from human induced pluripotent stem cells at an unprecedented efficiency and functionality. The core of the invention is the use of experimentally discovered mRNAs at multiple critical differentiation decision points along a pluripotent to mesendoderm to endoderm to pancreatic endocrine cells to pancreatic beta cells pathway in a previously unknown manner.本發明係關於一種以前所未有之效率及功能由人類誘導之多能幹細胞誘導或產生胰臟β細胞的新穎方法。本發明之核心在於在多個臨界分化決定點使用實驗上發現之mRNA以先前未知之方式沿多能至中內胚層至內胚層至胰臟內分泌細胞至胰臟β細胞之路徑來實現。
