As for this invention amino acid arrangement X1 X2 X3 X4 X5 X6 X7 (in formula, as for X1 the amino acid other than C, as for X2 the amino acid other than C, as for X3 the amino acid other than C, as for X4 the amino acid other than C, as for X5 the amino acid other than C, as for X6 it does not exist or or optional amino acid, X7 does not exist or or it is optional amino acid, X1 X2 X3 X4 X5 X6 is not DAEFRH.)Including, being something regarding the use in, producing the Alzheimers disease vaccine of the chemical compound which becomes, as for the said chemical compound there is an ability to connect with the unique antibody to natural A 42N terminal arrangement DAEFRH, furthermore as for those five quantitative bodies there is an ability to connect with the unique antibody to natural A 42N terminal arrangement DAEFRH.本発明はアミノ酸配列X1X2X3X4X5X6X7(式中、X1はC以外のアミノ酸、X2はC以外のアミノ酸、X3はC以外のアミノ酸、X4はC以外のアミノ酸、X5はC以外のアミノ酸、X6は存在しないかまたは任意のアミノ酸、X7は存在しないかまたは任意のアミノ酸であって、X1X2X3X4X5X6はDAEFRHではない。)を含んでなる化合物の、アルツハイマー病ワクチンの作製における使用に関するもので、該化合物は天然のAβ42N末端配列DAEFRHに特異的な抗体と結合する能力があり、さらにその五量体は天然のAβ42N末端配列DAEFRHに特異的な抗体と結合する能力がある。
