Interferon alpha mutant and its polyethylene glycol derivative

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专利权人:

北京三元基因工程有限公司

发明人:

リュウ、ジンイ,ニュウ、シャオシャ,ジョウ、ミンイ,ヤン、イ,ソン、ジェンボ,チェン、ヨンチン

申请号：

JP2009541739

公开号：

JP5407044B2

申请日:

2007.12.21

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

IFN-alpha mutants are obtained by substituting Cys for Tyr at position 85 or 86 in existing IFN-alpha. Their polyethylene glycol derivatives with high in vitro antiviral activity and prolonged in vivo half-life are also provided, wherein a polyethylene glycol moiety is covalently bound to the free Cys residue of an IFN-alpha mutant. The preparation methods of PEG derivatives of IFN-alpha mutants and medical compositions comprising the derivatives are also provided. The test results showed that the IFN-alpha mutants of the present invention are ready to prepare and have high activity； their polyethylene glycol derivatives have extended lifetime in the body and low clearance rate.

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中国工程科技知识中心

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