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Interferon alpha mutant and its polyethylene glycol derivative
专利权人:
Jinyi Liu
发明人:
Jinyi Liu,Xiaoxia Niu,Minyi Zhou,Yi Yang,Jianbo Sun,Yongqing Cheng
申请号:
US12519917
公开号:
US08168751B2
申请日:
2007.12.21
申请国别(地区):
US
年份:
2012
代理人:
摘要:
IFN-alpha mutants are obtained by substituting Cys for Tyr at position 85 or 86 in existing IFN-alpha. Their polyethylene glycol derivatives with high in vitro antiviral activity and prolonged in vivo half-life are also provided, wherein a polyethylene glycol moiety is covalently bound to the free Cys residue of an IFN-alpha mutant. The preparation methods of PEG derivatives of IFN-alpha mutants and medical compositions comprising the derivatives are also provided. The test results showed that the IFN-alpha mutants of the present invention are ready to prepare and have high activity their polyethylene glycol derivatives have extended lifetime in the body and low clearance rate.
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中国工程科技知识中心
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