CARDARELLI, JOSEPHINE M.,CLEMENS, WENDY L.,KROOG, GLENN S.,LOPES DE MENEZES, DANIEL E.,PAN, CHIN,PONATH, PAUL D.,VIALLET, JEAN
申请号：
CA2989144
公开号：
CA2989144A1
申请日:
2016.06.13
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
This disclosure provides a method for treating a subject afflicted with a cancer comprising administering to the subject a combination of therapeutically effective amounts of an antibody or an antigen-binding portion thereof that binds specifically to Programmed Death-1 (PD-1) or to Programmed Death Ligand-1 (PD-L1), and an antibody or an antigen-binding portion thereof that binds specifically to C-X-C Chemokine Receptor 4 (CXCR4) or to C-X-C motif chemokine 12 (CXCL12). The disclosure also provides a kit for treating a subject afflicted with a cancer, the kit comprising one or more dosages of an antibody or an antigen-binding portion thereof that binds specifically to PD-1 or to PD-L1, one or more dosages of an antibody or an antigen-binding portion thereof that binds specifically to CXCR4 or to CXCL12, and instructions for using the antibodies or portions thereof for treating the subject.
