Recombinant vitamin K dependent proteins with high sialic acid content and methods of preparing same

• 收藏
• 分享

专利权人:

发明人:

申请号：

EP12170422.5

公开号：

EP2517714A1

申请日:

2008.04.28

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

Methods of isolating highly sialylated recombinant vitamin K dependent proteins, particularly Factor IX, by chromatographic methods are described. The highly sialylated recombinant proteins are characterized. The improved Factor IX has at least 62% N-glycosyslation with 3 or 4 sialic acid residues and improved bioavailability and pharmokinetic properties.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/