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ADHÉSIF MÉDICAL POUR LA CHIRURGIE AVEC DES COMPOSÉS BIOACTIFS
专利权人:
BAYER MATERIALSCIENCE AG
发明人:
HECKROTH, HEIKE,KOEHLER, BURKHARD,DOERR, SEBASTIAN
申请号:
EP09718362.8
公开号:
EP2262546B1
申请日:
2009.02.21
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
Adhesive system comprises: (a) an isocyanate functionalized prepolymer obtained from an aliphatic isocyanate and a polyol with a number average molecular weight of >;= 400 g/mol and an average hydroxyl functionality of 2-6; (b) a hardener component comprising amino functionalized aspartic acid ester (I) and organic fillers exhibiting a viscosity of 10-6000 mPas at 23[deg] C, according to DIN 53019; (c) optionally conversion products of the isocyanate functionalized prepolymer with aspartic acid ester and/or organic filler; and (d) a compound. Adhesive system comprises: (a) an isocyanate functionalized prepolymer obtained from aliphatic isocyanate and polyol with a number average molecular weight of >;= 400 g/mol and an average hydroxyl functionality of 2-6; (b) a hardener component comprising amino functionalized aspartic acid ester of formula (X-(NH-CH(CH 2-COOR 2)-COOR 1) n) (I) and organic fillers exhibiting a viscosity of 10-6000 mPas at 23[deg] C, according to DIN 53019; (c) optionally conversion products of the isocyanate functionalized prepolymer with aspartic acid ester and/or organic filler; and (d) a compound. X : n-valent organic residue, which is obtained by removing primary amino groups of n-valent amine; R 1, R 2organic residue, which exhibits no Zerewitinoff active hydrogen; and n : 2. Independent claims are included for: (1) preparing the adhesive system, comprising mixing the components of (a), (b) and (d) and optionally (c) in a ratio of isocyanate-reactive groups to free isocyanate groups of 1:1.5-1:1; and (2) a two-chamber dosing system comprising the adhesive system, where the chamber comprises the components of (a)-(d). ACTIVITY : Vulnerary. MECHANISM OF ACTION : None given.
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