Adhesive composite system comprises an adhesive layer made from a tissue adhesive and a protective layer, which is applied on a surface of the adhesive layer, where: the tissue adhesive is based on hydrophilic polyurethane polymer and comprises (a) isocyanate functional prepolymer obtained from (a1) aliphatic isocyanate and (a2) polyol having average molecular weight of >= 400 g/mol and average hydroxyl functionality of 2-6, (b) aminofunctional aspartic acid ester (I) and/or (c) reaction product of (a) and (b) and the protective layer is water-proof layer. Adhesive composite system comprises an adhesive layer made from a tissue adhesive and a protective layer, which is applied on a surface of the adhesive layer, where: the tissue adhesive is based on hydrophilic polyurethane polymer and comprises (a) isocyanate functional prepolymer obtained from (a1) aliphatic isocyanate and (a2) polyol having average molecular weight of >= 400 g/mol and average hydroxyl functionality of 2-6, (b) aminofunctional aspartic acid ester of formula (X-[NH-CH(-CH 2-COOR2)-COOR1] n) (I) and/or (c) reaction product of (a) and (b) and the protective layer is water-proof layer. X : n-valent organic group that is obtained by removing a primary amino group of n-valent amine R1, R2 : organic residue comprising no Zerewitinoff-active hydrogen and n : at least 2. An independent claim is included for the preparation of the adhesive composite system comprising applying the adhesive layer made from the tissue adhesive on a substrate and applying the water-proof protective layer on the surface of the adhesive layer.본 발명은 조직 접착제의 접착제층 및 상기 접착제층의 표면에 적용된 보호층을 포함하고, 상기 조직 접착제는 친수성 폴리우레탄 중합체를 기재로 하고, 상기 보호층은 방수성인 복합 접착제 시스템에 관한 것이다. 또한, 본 발명은 상기 복합 접착제 시스템의 제조 방법, 상기 방법에 따라 얻어진 복합 접착제 시스템, 세포 조직을 커버하거나, 밀봉하거나, 접합시키기 위해 사용될 수 있는 복합 접착제 시스템 및 세포 조직을 커버하거나, 밀봉하거나, 접합시키기 위한 제품의 제조를 위한 복합 접착제 시스템의 용도에 관한 것이다.
