The present invention relates to a vaccine for infectious coryza of chickens, which comprises the recombinant haemagglutinin protein ofAvibacterium paragallinarumcontaining a hypervariable region. The present invention further provides a producing method for expression of the recombinant protein inE. coli, and the use thereof an effective component in vaccine composition to protect chickens against challenge infection withAv. paragallinarum.本發明係關於一種用於防治雞傳染性鼻炎之疫苗,其包含雞傳染性鼻炎菌(Avibacterium paragallinarum)之重組血球凝集素蛋白,該重組蛋白特徵在於包含一高度變化區序列。本發明進一步提供用於製備該重組血球凝集素疫苗之方法,包含以大腸桿菌生產包含該高度變化區序列之重組血球凝集素蛋白,以及將所得之重組蛋白作為有效之疫苗組成,以保護雞隻對抗雞傳染性鼻炎菌之感染。
