The invention relates to methods and compositions for treatment and diagnosis of diseases and disorders caused by or related to amyloid or amyloid protein, including amyloidosis.Specifically,The invention provides novel methods and compositions.In biology,Especially in animals,Especially in mammals or humans,To induce a highly specific and effective immune response.It can prevent or reduce amyloidosis.Or symptoms related to amyloidosis,A group of diseases or disorders associated with amyloidosis.Including secondary amyloidosis,And age-related amyloidosis,Including but not limited to neurological disorders (such as Alzheimer's disease (AD)),Including diseases or conditions characterized by loss of cognitive memory (such as mild cognitive impairment (MCI)).本發明係關於在由澱粉樣或類澱粉樣蛋白質引起，或與其有關之疾病和病症，包括澱粉樣變性的治療上，治療和診斷用途的方法和組合物。特定而言，本發明提供新穎的方法和組合物，在生物中，特別是在動物中，尤其是哺乳動物或人類中，誘發高度專一且高度有效的免疫反應，其可預防或減輕澱粉樣變性，或與澱粉樣變性有關之症狀，一群與澱粉樣斑形成有關的疾病或病症，包括繼發性澱粉樣變性，以及與年齡有關之澱粉樣變性，包括但不限於神經學的病症(如阿茲海默氏症(AD))，包括其特徵在於喪失認知記憶能力的疾病或狀況(例如輕微的認知損傷(MCI))。
