Disclosed herein is a novel sulfate salt of tianeptine with improved properties. Also described herein are novel pharmaceutical compositions comprising tianeptine sulfate salt, methods of making, and related methods of treatment.本文中揭露一種加強性能的新穎噻萘普汀硫酸鹽。本文中亦揭露包含噻萘普汀硫酸鹽的新穎醫藥組合物及其製法和相關治療方法。