FIG. 8 241 240 242 344 300 J 340 0 322 r- 362- 360 40 306 324 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 November 2018 (08.11.2018) WIP0 I Iiiimmolionsonomitimmomomilioniovois (10) International Publication Number WO 2018/204779 Al PCT 1-1 O N N O 71- 00 O O 1-1 (51) International Patent Classification: A61M 5/20 (2006.01) A61M 5/142 (2006.01) (21) International Application Number: PCT/US2018/031077 (22) International Filing Date: 04 May 2018 (04.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/502,278 05 May 2017 (05.05.2017) US (71) Applicant: REGENERON PHARMACEUTICALS, INC. [US/US]； 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). (72) Inventors: ARNOTT, Rachel； 249 Pierce Street, San Fran- cisco, CA 94117 (US). BARTON, Scott； c/o Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarry- town, NY 10591 (US). BURGESS, Bart, E.； c/o Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tar- rytown, NY 10591 (US). GILDERSLEEVE, Richard； c/ o Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill Riv- er Road, Tarrytown, NY 10591 (US). GORALTCHOUK, Alexei； c/o Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). GRYGUS, Bryan, C.； c/o Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). HAL- BIG, Daniel； c/o Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). KANEL, Christopher； c/o Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). LANGLEY, Trevor； c/o Regeneron Pharmaceuti- cals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). MARINO, Alfred； c/o Regeneron Pharmaceu- ticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US). (74) Agent: MA, Jameson； Bookoff McAndrews, PLLC, 2020 K Street, NW
