#$%^&*AU2015201986A120150507.pdf#####ABSTRACT The present invention relates to methods for inhibiting tumor growth or improving tolerability to at least one chemotherapeutic agent. The method comprises: (i) administering to a subject in need thereof an effective amount of a humanized monoclonal antibody or a functional fragment thereof, wherein the antibody or the fragment thereof has at least one complementarity determining region of murine monoclonal antibody BAT (mBAT-1) and a framework region (FR) from an acceptor human immunoglobulin, or modified therefrom； and (ii) administering to the subject an effective amount of at least one chemotherapeutic agent selected from the group consisting of an antimetabolite, a platinum-based agent and a mitotic inhibitor, wherein the humanized antibody is administered between 1 and 30 days before commencing chemotherapy, between 1 and 30 days after commencing chemotherapy, or according to an alternating schedule with the at least one chemotherapeutic agent； thereby treating the tumor or enhancing survival of the subject having the tumor. 501/20 FIGURE 1A 40 -4 0 0 0 0.5 0.75 hBAT-1 (pg/ml) FIGURE 1B 20 15 0. 10 0~ 0 72 Time (hr) FIGURE IC 60 -1Q 40 20 72 Time (hr)
