Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1

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专利权人:

Frank Himmelsbach;Matthias Eckhardt

发明人:

Matthias Eckhardt,Frank Himmelsbach

申请号：

US13147454

公开号：

US08637505B2

申请日:

2010.02.03

申请国别(地区):

US

年份:

2014

代理人:

摘要：

This invention relates to novel compounds of the Formula Formulas (I), (Ia1-20), (Ib1-20), (Ic1-20), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.

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