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Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
专利权人:
Frank Himmelsbach;Matthias Eckhardt
发明人:
Matthias Eckhardt,Frank Himmelsbach
申请号:
US13147454
公开号:
US08637505B2
申请日:
2010.02.03
申请国别(地区):
US
年份:
2014
代理人:
摘要:
This invention relates to novel compounds of the Formula Formulas (I), (Ia1-20), (Ib1-20), (Ic1-20), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
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