The compound of Formulas I and their preparation method, it is identical or different in R1, R2 and R3, and indicate hydrogen, halogen, alkyl, nitro, amino, alkyl-carbonyl-amino, alkyl amino or dialkyl amido R4 indicates alkyl, alkylaryl or heteroaryl X indicates CH2, oxygen atom or sulphur atom N is 2 or 3 Including individual (R values)-(sulphur) enantiomer or mixture of enantiomers Itself and including its pharmaceutically acceptable salt and ester. The compound has potential valuable pharmaceutical properties for treating cardiovascular disease such as hypertension and heart failure.
