LIN, FENG HUEI,林峰辉,林峰輝,张至宏,張至宏,LIAO, TAI CHIEH,廖泰杰,廖泰傑,FANG, HSU WEI,方旭伟,方旭偉,许元铭,許元銘,陈佳君,陳佳君
申请号：
TW098142010
公开号：
TWI400101B
申请日:
2009.12.09
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
A kind of degradable bone cement of stimulation angiogenic injecting type for treating caput femoris necrosis, system is by degradable poly- two hydroxypropyl acrylate of fumaric acid of material (poly (propylene fumarate)) and calcium-phosphate cement (calcium phosphate cement), addition ginsenoside Rg1 (ginsenoside Rg1) is made intensity and is enough to support the femoral head defect through core decompression processing, other than having the advantages of low what body temperature of solidification temperature will not injure tissue, characteristic also degradable using bone-cement biological, promotion angiogenic factor Rg1 in release mixing what bone cement ingredient. Experiment in vitro confirms Rg1 effective dose release time up to three weeks or more, there is statistically significant effect at blood vessel to promotion epithelial cell type, intended application what clinic can accelerate early stage Gu More to close, the enough mechanical strengths of bone defect are provided, promote femoral head angiogenesis, and most Hou replaces by body metabolism and by normal bone tissues.一種治療股骨頭壞死之刺激血管新生性注射式可降解骨水泥，係由可降解的材料聚富馬酸二羥丙酯(poly(propylene fumarate))及磷酸鈣水泥(calcium phosphate cement)，添加人參皂苷Rg1(ginsenoside Rg1)製成強度足以支撐經核心減壓術處理之股骨頭缺陷，除了有固化溫度低於體溫不會傷害人體組織的優點之外，還利用骨水泥生物可降解的特性，釋放混合於骨水泥成分中之促進血管新生因子Rg1。體外實驗證實Rg1有效劑量釋放時間可達三週以上，對促進上皮細胞型成血管具有統計學上顯著的功效，預期應用於臨床可加速早期骨癒合，提供骨缺損足夠的機械強度，促進股骨頭血管新生，且最後被人體代謝並由正常骨組織取代。
