IBRAHIM PRABHA N,SPEVAK WAYNE,CHO HANNA,SHI SONGYUAN,ZHANG CHAO,ZHANG YING
申请号：
IN4303/CHENP/2012
公开号：
IN2012CN04303A
申请日:
2012.05.15
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof arc active on at least one Raf protein kinase. In certain aspects and embodiments, the described compounds are active in inhibiting proliferation of a Ras mutant cell line. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of B-RafV600E mutant protein kinase, including melanoma, glioma glioblastoma multiforme, pilocytic astrocytoma, colcrectal cancer, thyroid cancer, lung cancer, ovarian cancer, prostate cancer, liver cancer, gallbladder cancer, gastrointestinal stromal tumors, biliary tract cancer, and cholangiocar cinoma Also described are methods of use thereof to treat diseases and conditions including diseases and conditions associated with activity of c-Raf-I protein kinase, including acute pain, chronic pain or polycystic kidney disease.
