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Fused heterocyclic compounds as ion channel modulators
专利权人:
Gilead Sciences; Inc.
发明人:
Elfatih Elzein,Dmitry Koltun,Xiaofen Li,Jeff Zablocki,Chandrasekar Venkataramani
申请号:
US13789469
公开号:
US08697863B2
申请日:
2013.03.07
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I:wherein Z1, Z2, Z3, Z4, X, Y, R2, R3 and R4 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
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