BAVETSIAS, VASSILIOS,ATRASH, BUTRUS,NAUD, SEBASTIEN GASTON ANDRE,SHELDRAKE, PETER WILLIAM,BLAGG, JULIAN
申请号：
CA2830143
公开号：
CA2830143C
申请日:
2012.03.14
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present invention relates to the use of certain pyrrolopyridineamino derivatives (hereinafter referred to as "PPA derivatives"), particularly 1H-pyrrolo[3,2-c]pyridine-6- amino derivatives, to inhibit the spindle checkpoint function of Monospindle 1 (Mps1 also known as TTK) kinases either directly or indirectly via interaction with the Mps kinase itself. In particular, the present invention relates to PPA derivatives for use as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of the PPA derivatives, and pharmaceutical compositions comprising them. Formula (I)
