BAVETSIAS VASSILIOS,ATRASH BUTRUS,NAUD Sébastien Gaston André,SHELDRAKE PETER WILLIAM,BLAGG JULIAN
申请号：
IN1856/MUMNP/2013
公开号：
IN2013MN01856A
申请日:
2013.10.04
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
The present invention relates to the use of certain pyrrolopyridineamino derivatives (hereinafter referred to as "PPA derivatives") particularly 1H pyrrolo[3 2 c]pyridine 6 amino derivatives to inhibit the spindle checkpoint function of Monospindle 1 (Mps1 also known as TTK) kinases either directly or indirectly via interaction with the Mps kinase itself. In particular the present invention relates to PPA derivatives for use as therapeutic agents for the treatment and/or prevention of proliferative diseases such as cancer. The present invention also relates to processes for the preparation of the PPA derivatives and pharmaceutical compositions comprising them. Formula (I)
