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USE OF GLUCOCORTICOID RECEPTOR ANTAGONISTS IN COMBINATION WITH GLUCOCORTICOIDS TO TREAT ADRENAL INSUFFICIENCY
专利权人:
Inc.;Corcept Therapeutics
发明人:
Andreas G. MORAITIS,Pejman COHAN,Joseph K. BELANOFF
申请号:
US16816014
公开号:
US20200206243A1
申请日:
2020.03.11
申请国别(地区):
US
年份:
2020
代理人:
摘要:
This invention provides for a method of h eating secondary adrenal insufficiency by co-administrating therapeutically effective amounts of a glucocorticoid and a glucocorticoid receptor antagonist to the patient in need thereof. In some embodiments, the method includes the proviso that the patient not be otherwise in need of treatment with a glucocorticoid and a glucocorticoid receptor antagonist. The treatment method can increase the patient's morning or basal cortisol level to at least about 12 μg/dL or a standard control level, and in turn, expedite significantly the recovery of the HPA axis. The method provided herein can improve health outcomes and life-threatening complications associated with secondary adrenal insufficiency.
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